Naproxen

Naproxen was originally marketed as the [|prescription drug] **Naprosyn** by [|Syntex] in 1976, and naproxen sodium was first marketed under the trade name **Anaprox** in 1980. It remains a prescription-only drug in much of the world. In the United States, the [|Food and Drug Administration] (FDA) approved its use as an [|over-the-counter (OTC) drug] in 1994; OTC preparations in the U.S. are mainly marketed by [|Bayer HealthCare] under the trade name **Aleve** and generic [|store brand] formulations. In Australia, packets of 275 mg tablets of naproxen sodium are [|Schedule 2 pharmacy medicines], with a maximum daily dose of 5 tablets or 1375 mg. In the United Kingdom, 250 mg tablets of naproxen were approved for OTC sale under the brand name **Feminax Ultra** in 2008, for the treatment of primary [|dysmenorrhoea] in women aged 15 to 50. [|[1]] Aleve became available over-the-counter in most provinces in Canada on 14 July 2009; it became available in [|Quebec] during the summer of 2010 but can only be dispensed by a pharmacy employee after an assessment of the patient's needs. It most recently became available in [|British Columbia] in March 2011. [|[2]]
 * Naproxen sodium** is a [|nonsteroidal anti-inflammatory drug] (NSAID). Naproxen and **naproxen sodium** are marketed under various trade names, including: **Aleve**, **Anaprox**, **Antalgin**, **Feminax Ultra**, **Flanax**, **Inza**, **Midol Extended Relief**, **Nalgesin**, **Naposin**,**Naprelan**, **Naprogesic**, **Naprosyn**, **Narocin**, **Proxen**, **Synflex** and **Xenobid**.

Naproxen was originally marketed as the prescription drug Naprosyn by Syntexin in 1976, and naproxen sodium was first marketed under the trade name Anaproxin in 19080. It remains a prescription -only drug in much of the world. In the United States, the FDA approved its use as an over-the-counter drug in 1994.

Like other medications, it is commonly used for fever, pain, and swelling.

Naproxen can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use naproxen.Naproxen can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation. These conditions can be fatal; older adults may have an even greater risk of these serious gastrointestinal side effects.  

Synthesis
Naproxen has been industrially produced by Syntex as follows: [|[9]]

Uses
Naproxen is commonly used for the reduction of [|pain], [|fever] , [|inflammation] , and stiffness caused by conditions including [|migraine] , [|osteoarthritis] , [|kidney stones] , [|rheumatoid arthritis] , [|psoriatic arthritis] , [|gout] , [|ankylosing spondylitis] , [|menstrual cramps] , [|tendinitis] , and [|bursitis]. [|[3]] It is also used for the treatment of primary [|dysmenorrhea]. [|[4]] Naproxen works by inhibiting both the [|COX-1] and [|COX-2] [|enzymes]. 