Ornithine

Role in urea cycle L -Ornithine is one of the products of the action of the enzyme [|arginase] on L -[|arginine], creating [|urea]. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess [|nitrogen]. Ornithine is recycled and, in a manner, is a catalyst. First, ammonia is converted into [|carbamoyl phosphate] (phosphate-CONH 2 ), which creates one half of urea. Ornithine is converted into a urea derivative at the δ (terminal) nitrogen by carbamoyl phosphate. Another nitrogen is added from [|aspartate], producing the denitrogenated [|fumarate] , and the resulting [|arginine] (a [|guanidinium] compound) is hydrolysed back to ornithine, producing urea. The nitrogens of urea come from the ammonia and aspartate, and the nitrogen in ornithine remains intact. <span style="background-color: #f9f9f9; border-bottom-color: #cccccc; border-bottom-style: solid; border-bottom-width: 1px; border-image: initial; border-left-color: #cccccc; border-left-style: solid; border-left-width: 1px; border-right-color: #cccccc; border-right-style: solid; border-right-width: 1px; border-top-color: #cccccc; border-top-style: solid; border-top-width: 1px; display: block; font-size: 12px; min-width: 100px; overflow-x: hidden; overflow-y: hidden; padding-bottom: 3px !important; padding-left: 3px !important; padding-right: 3px !important; padding-top: 3px !important; text-align: center; width: 222px;"> <span style="background-attachment: initial !important; background-clip: initial !important; background-color: initial !important; background-image: none !important; background-origin: initial !important; border-bottom-style: none !important; border-color: initial !important; border-color: initial !important; border-left-style: none !important; border-right-style: none !important; border-top-style: none !important; border-width: initial !important; border-width: initial !important; color: #0b0080; display: block; float: right; text-decoration: none;"> Ornithine lactamization Ornithine is not an amino acid coded for by [|DNA], and, in that sense, is not involved in [|protein synthesis]. However, in mammalian non-hepatic tissues, the main use of the urea cycle is in arginine biosynthesis, so, as an intermediate in metabolic processes, ornithine is quite important. It is believed not to be a part of genetic code because polypeptides containing unprotected ornithines undergo spontaneous [|lactamization] .<span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; color: #0b0080; line-height: 1em; text-decoration: none; white-space: nowrap;">[|[2]]
 * Ornithine ** is an <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; color: #0b0080; font-family: sans-serif; text-decoration: none;">[|amino acid] that plays a role in the <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; color: #0b0080; font-family: sans-serif; text-decoration: none;">[|urea cycle] . Ornithine is abnormally acumulated in the body in <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; color: #0b0080; font-family: sans-serif; text-decoration: none;">[|ornithine transcarbamylase deficiency].

Taking __ Ornithine __ has been said to help detoxify your liver and help with a gall bladder infection. It is available for purchase in tablet form.
 * ~ Properties<span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; color: #0b0080; line-height: 1em; text-decoration: none; white-space: nowrap;">[|[1]] ||
 * <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|Molecular formula] || C 5 H 12 N 2 O 2 ||
 * <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|Molar mass] || 132.16 g/mol ||
 * <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|Melting point] || 140 ºC ||
 * <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|Solubility] in <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|water] || soluble ||
 * <span style="background-attachment: initial; background-clip: initial; background-color: initial; background-image: none; background-origin: initial; background-position: initial initial; background-repeat: initial initial; color: #0b0080; text-decoration: none;">[|Chiral rotation] [α] D || +11.5 (H 2 O, //c// = 6.5) ||

Ornithine, via the action of [|ornithine decarboxylase] (E.C. 4.1.1.17), is the starting point for the synthesis of [|polyamines] such as [|putrescine].