Crospovidone

Crospovidone


// 1] **Description:** // White, free flowing, compressible powder. A synthetic homopolymer of cross-linked N-vinyl-2-pyrrolidone. Solubility: Completely insoluble in water, acids, alkalis, and all organic solvents. Hygroscopic. Swells rapidly in water. Rapidly disperses in water, but does not gel even after prolonged exposure. Chemical Activity: Chemically inert. Has a high adsorptive capacity, forms reversible physical complexes with many molecules without the formation of covalent chemical bonds. // 2] **Physical Characteristics:** // pH (10% slurry): 5.0 – 8.0 Moisture (Karl-Fisher): £ 5.0%


 * ** Product ** || ** Typical Average Particle size (microns) ** || ** Tap Density (g/cc) ** || ** Bulk Density (g/cc) ** ||
 * ** Polyplasdone XL ** || 100 || 0.3 || 0.2 ||
 * ** Polyplasdone XL-10 ** || 30 || 0.5 || 0.3 ||
 * ** Polyplasdone INF-10 ** || 11 || 0.5 || 0.4 ||

// 3] **Applications:** //

    "Pformulate Excipients - Crospovidone." //P Formulate.com //. Pformulate, 8 Mar. 2000. Web. 24 Apr. 2012. .
 * Wet granulation || Disintegrant/super-disintegrant ||
 * Dry granulation || Greatest rate of swelling compared to other disintegrants ||
 * Direct compression || Greater surface area to volume ratio than other disintegrants typically used at a level of 1 to 3% ||
 * || Dissolution aid for tablets, capsules and pellets ||
 * Direct compression || Greater surface area to volume ratio than other disintegrants typically used at a level of 1 to 3% ||
 * || Dissolution aid for tablets, capsules and pellets ||