Lysergic+acid

= Lysergic acid = Also known as LSD

Lysergic acid

Lysergic acid is generally produced by hydrolysis of natural lysergamides, but can also be synthesized in the laboratory by a complex total synthesis for example by Woodward's team in 1956 An enantioselective total synthesis based on a palladium catalyzed domino cyclization reaction has been described in 2011 by Fujii and Ohno. Lysergic acid monohydrate crystallizes in very thin hexagonal leaflets when recrystallized from water. Lysergic acid monohydrate, when dried (140 °C at 2 mmHg or 270 Pa) forms anhydrous lysergic acid. The biosynthetic route is based on the alkylation of the amino acid Tryptophan with dimethylallyl diphosphate (isoprene derived from 3R-mevalonic) giving 4-dimethylallyl-L-tryptophan which is N-methylated with S-adenosyl methionine. Oxidative ring closure followed by decarboxylation, reduction, cyclization, oxidation, and allylic isomerization yields D-(+)-lysergic acid.

===** Lysergic acid **, is a precursor for a wide range of alkaloids that are produced by fungus and some plants. Amides of lysergic acid, are widely used as pharmaceuticals and as a psychedelic drug known as LSD. Lysergic acid received its name as it was a product of the lysis of various ergot alkaloids. There is an isomer of Lysergic acid with an inverted configuration at the eight atom of the carboxyl group. This acid is used in many different chemicals. ===